Biologics & Diagnostics Engineering Laboratory

"Plant-derived EVs: current status and challenges for developing a new paradigm in therapeutics development" VIEW 6:20240115 (2025)  Journal cover

"IL-2 surface displayed M1 macrophage-derived EVs for modulating the tumor microenvironment" International Journal of Nanomedicine 20:14185-14200 (2025)

"Engineered plant-derived extracellular vesicles for targeted regulation and treatment of colitis-associated inflammation" Theranostics 14:5643-5661 (2024)  Journal cover

"Exploiting spinach-derived extracellular vesicles for anti-obesity therapy through lipid accumulation inhibition" Advanced Therapeutics 7:2400150 (2024)  Journal cover

"Bioreducible exosomes encapsulating glycolysis inhibitors potentiate mitochondria-targeted sonodynamic cancer therapy via cancer-targeted drug release and cellular energy depletion" Biomaterials 301:122242 (2023)

"Brain endothelial cell-derived extracellular vesicles with a mitochondria-targeting photosensitizer effectively treat glioblastoma by hijacking the blood‒brain barrier” Acta Pharmaceutica Sinica B 13:3834-3848 (2023)

"Size-selective filtration of extracellular vesicles with a movable-layer device" Lab on a Chip 22:3699 (2022)

"Engineered extracellular vesicle-based sonotheranostics for dual stimuli-sensitive drug release and photoacoustic imaging-guided chemo-sonodynamic cancer therapy" Theranostics (2022)  Journal cover

"Inhibition of tumor progression and M2 microglial polarization by extracellular vesicle-mediated microRNA-124 in a 3D microfluidic glioblastoma microenvironment" Theranostics 11:9687-9704 (2021) Journal cover

"Single-step equipment-free extracellular vesicle concentration using super absorbent polymer beads" Journal of Extracellular Vesicles 10:e12074 (2021)

"Isolation of cabbage exosome-like nanovesicles and investigation of their biological activities in human cells" Bioactive Materials 6:4321-4332 (2021)

"Safe and targeted sonodynamic cancer therapy using biocompatible exosome-based nanosonosensitizers" ACS Applied Materials & Interfaces 13:25575-25588 (2021)

"Exosome-mediated microRNA-497 delivery for anti-cancer therapy in a microfluidic 3D lung cancer model" Lab on a Chip 20:548 (2020)

"Simultaneous multiplexed detection of exosomal miRNAs and surface proteins for prostate cancer diagnosis" Biosensors and Bioelectronics 146:111749 (2019)

"Inhibition of apoptosis using exosomes in Chinese hamster ovary cell culture" Biotechnology and Bioengineering 115:1331-1339 (2018)

“Simultaneous and multiplexed detection of exosome microRNAs using molecular beacons” Biosensors and Bioelectronics 86:202-210 (2016)

"In situ single step detection of exosome microRNA using molecular beacon" Biomaterials, 54:116-125 (2015)    

“Enzyme delivery using the 30Kc19 protein and human serum albumin nanoparticles” Biomaterials 35:1696-1704 (2014) 

"High-throughput generation of spheroids using magnetic nanoparticles for three-dimensional cell culture" Biomaterials 34: 8555-8563 (2013)  

"A Protein delivery system using 30Kc19 cell-penetrating protein originating from silkworm" Biomaterials 33: 9127-9134 (2012).   

“Quantum dot-fluorescent protein FRET probes for sensing intracellular pH” ACS Nano 6: 2917-2924 (2012).      

“Enhancement of neurite outgrowth in PC12 cells by iron oxide nanoparticles” Biomaterials 32: 2871-2877 (2011). 

“HuR regulates the expression of stress-sensitive genes and mediates inflammatory response in human umbilical vein endothelial cells”  PNAS 107:6858-6863 (2010).

“Use of molecular beacons to image effects of titanium surface microstructure on β1 integrin expression in live osteoblast-like cells” Biomaterials, 31: 7640-7647 (2010).  

“Slow non-specific accumulation of 2’-deoxy and 2’-O-methyl oligonucleotide probes at mitochondria in live cells” Nucleic Acids Research, 38: e109 (2010). 

“Translation inhibition reveals interaction of 2’-deoxy and 2’-O-methyl molecular beacons with mRNA targets in living cells” Nucleic Acids Research, 37:4977-4986 (2009).

“Fluorescent probes for live-cell RNA detection” Annual Review of Biomedical Engineering, 11:25-47 (2009). 

“Target accessibility and signal specificity in live-cell detection of BMP-4 mRNA using molecular beacons” Nucleic Acids Research, 36. e30 (2008).