Biologics & Diagnostics Engineering Laboratory

     2023  

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• Ji Yoon Lee, Soye Lee, Haneul Lee, Tham Troung Phuong Tran, Byoung Choul Kim, Won Jong Rhee  "In situ simultaneous detection of surface protein and microRNA in clustered extracellular vesicles from cancer cell lines using flow cytometry" ACS Biomaterials Science & Engineering (Accepted)   IF 5.7

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• Do Kyung Kim, Su Jin Kang,  Won Jong Rhee "Perilla leaf-derived extracellular vesicles selectively inhibit breast cancer cell proliferation and invasion" International Journal of Molecular Sciences (Accepted)    IF 6.208

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• Thuy Giang Nguyen Caoa, Ji Hee Kangb, Su Jin Kang, Quan Truong Hoang, Han Chang Kang, Won Jong Rhee*,Yu Shrike Zhange*, Young Tag Kob*, Min Suk Shim* “Brain endothelial cell-derived extracellular vesicles with a mitochondria-targeting photosensitizer effectively treat glioblastoma by hijacking the blood‒brain barrier” Acta Pharmaceutica Sinica B 13:3834-3848 (2023)    IF 14.907

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• Thuy Giang Nguyen Cao, Quan Truong Hoang, Ji Hee Kang, Su Jin Kang, Won Jong Rhee*, Minjong Lee*, Young Tag Ko*, Min Suk Shim* “Bioreducible exosomes encapsulating glycolysis inhibitors potentiate mitochondria-targeted sonodynamic cancer therapy via cancer-targeted drug release and cellular energy depletion” Biomaterials 301:122242 (2023)   IF 15.304

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• Thuy Giang Nguyen Cao, Quan Truong Hoang, Eun Ji Hong, Su Jin Kang, Ji Hee Kang, Vasanthan Ravichandran, Han Chang Kang, Young Tag Ko, Won Jong Rhee, Min Suk Shim “Mitochondria-targeting sonosensitizer-loaded extracellular vesicles for chemo-sonodynamic therapy” Journal of Controlled Release 354:651-663 (2023)      IF 11.467

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• Quan Truong Hoang, Thuy Giang Nguyen Cao, Su Jin Kang, Minjong Lee, Ji Hee Kang, Hyun Su Park, Jong-Eun Kim, Suk Ho Bhang, Young Tag Ko, Won Jong Rhee, Min Suk Shim  “Exosome membrane-sheathed and multi-stimuli-responsive MnO2 nanoparticles with self-oxygenation and energy depletion abilities potentiate the sonodynamic therapy of hypoxic tumors” Chemical Engineering Journal  472:144871 (2023)    IF 16.744

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     2022  

 

• Islam Seder, Hyomin Moon, Su Jin Kang, Korakot Boonyaphon, Sehyun Shin, Won Jong Rhee*, Sung-Jin Kim* "Size-selective filtration of extracellular vesicles with movable-layer device" Lab on a Chip 22:3699-3707 (2022)    IF 7.517

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• Su Jin Kang, Si Eun Kim, Myung-Ji Seo, Eunjung Kim, Won Jong Rhee "Suppression of  inflammatory responses in macrophages by onion-derived extracellular vesicles" Journal of Industrial and Engineering Chemistry 115:287-297 (2022)    IF 6.76

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• Thuy Giang Nguyen Cao, Ji Hee Kang, Wangyu Kim, Junha Lim, Su Jin Kang, Jae Young You, Quan Truong Hoang, Won Jong Kim, Won Jong Rhee*, Chulhong Kim*, Young Tag Ko*, Min Suk Shim* "Engineered extracellular vesicle-based sonotheranostics for dual stimuli-sensitive drug release and photoacoustic imaging-guided chemo-sonodynamic cancer therapy" Theranostics 12:1247-1266 (2022)     IF 11.556    Journal Cover

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• Haneul Lee, Su Jin Kang, Jimin Lee, Kyong Hwa Park, Won Jong Rhee "Isolation and characterization of urinary extracellular vesicles from healthy donors and patients with castration-resistant prostate cancer" International Journal of Molecular Sciences 23:7134 (2022)   IF 6.208

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• Chi Young Hwang, Eui-Sang Cho, Won Jong Rhee, Eunjung Kim, Myung-Ji Seo "Genomic and physiological analysis of C50 carotenoid-producing novel Halorubrum ruber sp. nov." Journal of Microbiology 60 (2022)  IF 3.422

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• Dain Kim, Jiyoung Lee, Sangwoo Park, Juhyeon Park, Myung-Ji Seo, Won Jong Rhee, Eunjung Kim "Target-responsive template structure switching-mediated exponential rolling circle amplification for the direct and sensitive detection of microRNA" BioChip Journal (2022)  IF 4.229

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• Sumin Kim, Ji Hee Kang, Thuy Giang Nguyen Cao, Su Jin Kang, Kyeongsoo Jeong, Han Chang Kang, Young Jik Kwon, Won Jong Rhee*, Young Tag Ko*, Min Suk Shim* "Extracellular vesicles with high dual drug loading for safe and efficient combination chemo-phototherapy" Biomaterials Science 10:2817-2830 (2022)   IF 7.590

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     2021

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• Hee Cheol Yang, Yoo Min Ham, Jeong Ah Kim, Won Jong Rhee  "Single-step equipment-free extracellular vesicle concentration using super absorbent polymer beads" Journal of Extracellular Vesicles 10:e12074 (2021)    IF 17.337

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• Jae Young You, Su Jin Kang, Won Jong Rhee  "Isolation of cabbage exosome-like nanovesicles and investigation of their biological activities in human cells" Bioactive Materials 6:4321-4332 (2021)    IF 16.874

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• Soohyun Hong, Jae Young You, Kyurim Paek, Jubin Park, Su Jin Kang, Eun Hee Han, Nakwon Choi, Seok Chung, Won Jong Rhee*, Jeong Ah Kim* "Inhibition of tumor progression and M2 microglial polarization by extracellular vesicle-mediated microRNA-124 in a 3D microfluidic glioblastoma microenvironment"  Theranostics  11:9687-9704 (2021)         IF 11.556  Journal Cover

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• Thuy Giang Nguyen Cao, Ji Hee Kang, Jae Young You, Han Chang Kang, Won Jong Rhee*, Young Tag Ko*, Mn Suk Shim* "Safe and targeted sonodynamic cancer therapy using biocompatible exosome-based nanosonosensitizers" ACS Applied Materials & Interfaces 13:25575-25588 (2021)    IF 10.383

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• Do Kyung Kim, Won Jong Rhee "Antioxidative effects of carrot-derived nanovesicles in cardiomyoblast and neuroblastoma cells" Pharmaceutics 13:1203 (2021)   IF 6.525

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• Hee Cheol Yang, Won Jong Rhee"Single step in situ detection of surface protein and microRNA in clustered extracellular vesicles using flow cytometry" Journal of Clinical Medicine 10:310 (2021)    IF 4.964

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• Haneul Kim, Su Jin Kang, Won Jong Rhee "Phenylboronic acid-conjugated exosomes for enhanced anticancer therapeutic effect by increasing doxorubicin loading efficiency" Biotechnology and Bioprocess Engineering 26:78-85 (2021)   IF 3.386

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      2020

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• Kyeongsoo Jeong, Yeong Jun Yu, Jae Young You, Won Jong Rhee*, Jeong Ah Kim* “Exosome-mediated microRNA-497 delivery for anti-cancer therapy in a microfluidic 3D lung cancer model” Lab on a Chip 20:548-557  (2020)    IF 7.517

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• Anandrao Ashok Patil, Sachin Ashok Bhor, Won Jong Rhee "Cell death in culture: Molecular mechanisms, detection, and inhibition strategies" Journal of Industrial and Engineering Chemistry 91:37-53 (2020)    IF 6.760

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• Jungyeon Heo, Hee Cheol Yang, Won Jong Rhee, Hara Kang "Vascular smooth muscle cell-derived exosomal miRNAs regulate endothelial cell migration under PDGF stimulation" Cells 9:639  (2020)  IF 7.666

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• Haneul Kim, Won Jong Rhee "Exosome-mediated let7c-5p delivery for breast cancer therapeutic development" Biotechnology and Bioprocess Engineering 25:513-520 (2020)    IF 3.386

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• Seongcheol Cho, Hee Cheol Yang, Won Jong Rhee “Development and comparative analysis of human urine exosome isolation strategies” Process Biochemistry 88:197-203 (2020)    IF4.885

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• Sungjin Park, Kiyoung Lee, Ie Byung Park, Nan Hee Kim, Seongcheol Cho, Won Jong Rhee, Yujin Oh, Jimin Choi, Seungyoon Nam, Dae Ho Lee "The profiles of microRNAs from urinary EVs prepared by various isolation methods and their correlation with serum EV microRNAs" Diabetes Research and Clinical Practice 160:108010 (2020)   IF 8.180

 

      2019

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• Seongcheol Cho, Hee Cheol Yang, Won Jong Rhee “Simultaneous multiplexed detection of exosomal microRNAs and surface proteins for prostate cancer diagnosis” Biosensors and Bioelectronics 146:111749​ (2019)    IF 12.545

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• Jeong Ah Kim, Soohyun Hong, Won Jong Rhee “Microfluidic three-dimensional cell culture of stem cells for high-throughput analysis” World Journal of Stem Cells 11:803-816 ​ (2019)   IF 5.247

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• Chae Rin Park, Won Jong Rhee, Kyu Won Kim, Byeong Hee Hwang "Colorimetric biosensor using dual-amplification of enzyme-free reaction through universal hybridization chain reaction system" Biotechnology and Bioengineering 116:1567-1574 ​ (2019)   IF 4.395

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• Kyeongsoo Jeong, Seunga Jeong, Jeong Ah Kim, Won Jong Rhee "Exosome-based antisense locked nucleic acid delivery for inhibition of type II collagen degradation in chondrocyte" Journal of Industrial and Engineering Chemistry 74:126-135 ​ (2019)   IF 6.760

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• Su Jin Kang, Won Jong Rhee "Silkworm storage protein 1 inhibits autophagy-mediated apoptosis" International Journal of Molecular Sciences 20:318 ​ (2019)   IF 6.208

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• Anandrao Ashok Patil, Won Jong Rhee “Exosomes: Biogenesis, composition, functions, and their role in pre-metastatic niche formation” Biotechnology and Bioprocess Engineering 24:689-701 ​ (2019)   IF 3.386

 

      2018

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• Jinhee Lee, Min Hee Kwon, Jeong Ah Kim, Won Jong Rhee “Detection of exosome miRNAs using molecular beacons for diagnosing prostate cancer” Artificial Cells, Nanomedicine, and Biotechnology 46:S52-S63  (2018)  IF 6.355

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• Seora Han, Won Jong Rhee “Inhibition of apoptosis using exosomes in Chinese hamster ovary cell culture” Biotechnology and Bioengineering 115:1331-1339 (2018)    IF 4.395

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• Myeongsik Oh, Jinhee Lee, Yu Jin Kim, Won Jong Rhee, Ju Hyun Park “Exosomes derived from human induced pluripotent stem cells ameliorate the aging of skin fibroblasts” International Journal of Molecular Sciences, 19:1715  (2018)  IF 6.208

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• Yeon Ju Cha, Ji Eun Baik, Won Jong Rhee “Inhibition of endoplasmic reticulum stress-induced apoptosis by silkworm storage protein 1” Biotechnology and Bioprocess Engineering 23:194-200 (2018)  IF 3.386

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• MubarakAli Davvdbasha, Bo-Ram Park, Won Jong Rhee, Sang-Yul Lee, Jung-Wan Kim “Antioxidant potentials of nanoceria synthesized by solution plasma process and its biocompatibility study” Archives of Biochemistry and Biophysics 645:42-49 (2018)   IF 4.114

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• Suk Ho Bhang, Kyuwon Kim, Won Jong Rhee, Min Suk Shim "Bioreducible polyspermine-based gene carriers for efficient siRNA delivery: Effects of PEG conjugation on gene silencing efficiency" Macromolecular Research 26:1135-1142 (2018)   IF 2.127

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      2017

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• Ji Hye Lee, Ji Eun Baik, Won Jong Rhee “Anti-oxidative effects of silkworm storage protein 1 in HeLa cell" Process Biochemistry 55:199-206 (2017)    IF 4.885

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• Ji Eun Baik, Won Jong Rhee “Anti-apoptotic effects of the alpha-helix domain of silkworm storage protein 1” Biotechnology and Bioprocess Engineering 22:671-678 (2017)    IF 3.386

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      2016

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• Ji Hye Lee, Jeong Ah Kim, Seunga Jeong, Won Jong Rhee “Simultaneous and multiplexed detection of exosome microRNAs using molecular beacons” Biosensors and Bioelectronics  86:202-210 (2016)     IF 12.545

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• Jina Ryu, Hyoju Kim, Hee Ho Park, Hong Jai Lee, Ju Hyun Park, Won Jong Rhee, Tai Hyun Park “Protein-stabilizing and cell-penetrating properties of a-helix domain of 30Kc19 protein” Biotechnology Journal 11:1443-1451 (2016) Journal Cover       IF 4.677

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• Hong Jai Lee, Hee Ho Park, Youngsoo Sohn, Jina Ryu, Ju Hyun Park, Won Jong Rhee, Tai Hyun Park “a-Galactosidase delivery using 30Kc19-human serum albumin nanoparticles for effective treatment of Fabry disease” Applied Microbiology and Biotechnology 100:10395-10402 (2016)      IF 4.813

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• Jina Ryu, Hee Ho Park, Ju Hyun Park, Hong Jai Lee, Won Jong Rhee, Tai Hyun Park “Soluble expression and stability enhancement of transcription factors using 30Kc19 cell-penetrating protein” Applied Microbiology and Biotechnology 100:3523-3532 (2016)      IF 5.560

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• Seunga Jeong, Won Jong Rhee “Live cell detection of monoclonal antibody light and heavy chain mRNAs using molecular beacons” KSBB J. 31:33-39 (2016) 

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      2015

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• Ji Hye Lee, Jeong Ah Kim, Min Hee Kwon, Ji Yoon Kang, Won Jong Rhee  "In situ single step detection of exosome microRNA using molecular beacon" Biomaterials 54:116-125  (2015)    IF 15.304

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• Hee Ho Park, Jeongseon Choi, Hong Jai Lee, Jina Ryu, Ju Hyun Park, Won Jong Rhee*, Tai Hyun Park* "Enhancement of human erythropoietin production in Chinese hamster ovary cells through supplementation of 30Kc19-30Kc6 fusion protein" Process Biochemistry 99:2155-2163  (2015)       IF 4.885

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• Ju Hyun Park, Hong Jai Lee, Hee Ho Park, Won Jong Rhee, Tai Hyun Park "Stabilization of cellular mitochondrial enzyme complex and sialytransferase activity through supplementation of 30Kc19 protein" Applied Microbiology and Biotechnology 99:2155-2163 (2015)       IF 5.560

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• Ji Hye Lee, Tai Hyun Park, Won Jong Rhee "Inhibition of apoptosis in HeLa cell by silkworm storage protein 1, SP1" Biotechnology and Bioprocess Engineering 20:807-813 (2015)      IF 3.386

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      2014

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• Hong Jai Lee, Hee Ho Park, Jeong Ah Kim, Ju Hyun Park, Jina Ryu, Jeoung Seon Choi, Jong Min Lee, Won Jong Rhee, Tai Hyun Park "Enzyme delivery using the 30Kc19 protein and human serum albumin nanoparticles"  Biomaterials, 35:1696-1704 (2014)     IF 15.304

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• Hee Ho Park, Youngsoo Sohn, Ji Woo Yeo, Ju Hyun Park, Hong Jai Lee, Jina Ryu, Won Jong Rhee, Tai Hyun Park "Dimerization of 30Kc19 protein in the presence of amphiphilic moiety and importance of Cys-57 during cell penetration" Biotechnology Journal, 9:1582-1593 (2014)    IF 4.677

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• Hee Ho Park, Youngsoo Sohn, Ji Woo Yeo, Ju Hyun Park, Hong Jai Lee, Jina Ryu, Won Jong Rhee, Tai Hyun Park "Identification and characterization of a novel cell-penetrating peptide of 30Kc19 protein derived from Bombyx mori" Process Biochemistry, 49:1516-1526 (2014)  IF 4.885

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• Hong Jai Lee, Hee Ho Park, Jeong Ah Kim, Ju Hyun Park, Jina Ryu, Jeongseon Choi, Jongmin Lee, Won Jong Rhee, Tai Hyun Park "Enzyme delivery using the 30Kc19 protein and human serum albumin nanoparticles" Biomaterials, 35: 1696-1704  (2014)    IF 15.304

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      2013

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• Jeong Ah Kim, Jong-Ho Choi, Minsoo Kim, Won Jong Rhee, Boram Son, Hyun-Kyo Jung, Tai Hyun Park "High-throughput generation of spheroids using magnetic nanoparticles for three-dimensional cell culture" Biomaterials 34: 8555-8563 (2013)    IF 15.304

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• Won Jong Rhee, Ju Hyun Park, Ji-Sook Hahn, Tai Hyun Park "Anti-apoptotic mechanism of silkworm hemolymph in HeLa cell apoptosis" Process Biochemistry 48:1375-1380 (2013)     IF 4.885

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• Mi-Ra Chang, Woong Hee Lee, Won Jong Rhee, Tai Hyun Park, Eun Jeong Kim "Anti-inflammatory effects of silkworm hemolymph on lipopolysaccharide-stimulated macrophages" Korean J. Chem. Eng. 30: 1784-1789  (2013)

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      2012

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• Ju Hyun Park, Ju Hyun Lee, Hee Ho Park, Won Jong Rhee, Shin Sik Choi, Tai Hyun Park "A Protein delivery system using 30Kc19 cell-penetrating protein originating from silkworm" Biomaterials 33:9127-9134 (2012)   IF 15.304

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• Jeong Ah Kim, Eui Yun Jang, Tae June Kang, Sungjun Yoon, Raquel Ovalle-Robles, Won Jong Rhee, Taewoo Kim, Ray H. Baughman, Yong Hyup Kim, Tai Hyun Park “Regulation of morphogenesis and neural differentiation of human mesenchymal stem cells using carbon nanotube sheets” Integrative Biology, 4: 587-594 (2012) Journal Cover    IF 3.177

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• Allison M. Dennis, Won Jong Rhee, David Sotto, Steven N. Dublin, Gang Bao “Quantum dot-fluorescent protein FRET probes for sensing intracellular pH” ACS Nano, 6: 2917-2924  (2012)  IF 18.027

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• Zesong Wang, Xuhui Ma, Li Fan, Won Jong Rhee, Tai Hyun Park, Liang Zhao, and Wen-Song Tan “Understanding the mechanistic roles of 30Kc6 gene in apoptosis and specific productivity in antibody-producing Chinese hamster ovary cells”  Applied Microbiology and Biotechnology, 94: 1243-1253 (2012)   IF 5.560    

 

     ~2011

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• Jeong Ah Kim, Nohyun Lee, Byung Hyo Kim, Won Jong Rhee, Sungjun Yoon, Taeghwan Hyeon, Tai Hyun Park “Enhancement of neurite outgrowth in PC12 cells by iron oxide nanoparticles” Biomaterials, 32: 2871-2877 (2011)      IF 15.304

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• Won Jong Rhee, Chih-Wen Ni, Zhilan Zheng, Kyunghwa Chang, Hanjoong Jo, Gang Bao “HuR regulates the expression of stress-sensitive genes and mediates inflammatory response in human umbilical vein endothelial cells”  Proc. Natl. Acad. Sci. U. S. A., 107:6858-6863 (2010)    IF 12.779

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• Frances Lennon, Chris Hermann, Rene Olivares-Navarette, Won Jong Rhee, Zvi Schwartz, Gang Bao, Barbara Boyan “Use of molecular beacons to image effects of titanium surface microstructure on β1 integrin expression in live osteoblast-like cells” Biomaterials, 31: 7640-7647 (2010)      IF 15.304

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• Won Jong Rhee, Gang Bao “Slow non-specific accumulation of 2’-deoxy and 2’-O-methyl oligonucleotide probes at mitochondria in live cells” Nucleic Acids Research, 38: e109 (2010)    IF 19.32

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• Nitin Nitin*, Won Jong Rhee* (*Co-1st author), Gang Bao “Translation inhibition reveals interaction of 2’-deoxy and 2’-O-methyl molecular beacons with mRNA targets in living cells” Nucleic Acids Research, 37:4977-4986 (2009)     IF 19.160

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• Gang Bao, Won Jong Rhee, Andrew Tsourkas “Fluorescent probes for live-cell RNA detection” Annual Review of Biomedical Engineering, 11:25-47 (2009).    IF 11.32

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• Nitin Nitin, Leslie LaConte, Won Jong Rhee, Gang Bao “Tat peptide is capable of importing large nanoparticles across nuclear membrane” Annals of Biomedical Engineering, 37:2018-2027 (2009).    IF= 3.934

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• Won Jong Rhee, Gang Bao “Simultaneous detection of mRNA and protein stem cell markers in live cells” BMC Biotechnology, 9:30 (2009).    “Highly Accessed Paper”  IF 3.329

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• Won Jong Rhee, Eun Hee Lee, Tai Hyun Park “Expression of Bombyx mori 30Kc19 protein in Escherichia coli and its anti-apoptotic effect in Sf9 cell” Biotechnology and Bioprocess Engineering, 14:645-650 (2009).  IF 3.386

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• Won Jong Rhee, Philip Santangelo, Hanjoong Jo, Gang Bao “Target accessibility and signal specificity in live-cell detection of BMP-4 mRNA using molecular beacons” Nucleic Acids Research, 36. e30 (2008).  IF 16.971

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• Won Jong Rhee, Eun Hee Lee, Ju Hyun Park, Ji Eun Lee, Tai Hyun Park, "Inhibition of HeLa cell apoptosis by storage-protein 2" Biotechnology Progress, 23, 1441-1446 (2007).  IF 2.334

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• Shin Sik Choi, Won Jong Rhee, Eun Jeong Kim, Tai Hyun Park "Enhancement of recombinant protein production in Chinese hamster ovary cells through anti-apoptosis engineering using 30Kc6 gene" Biotechnology and Bioengineering, 95, 459-467 (2006).    

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• Shin Sik Choi, Won Jong Rhee, Tai Hyun Park "Beneficial Effect of Silkworm Hemolymph on a CHO Cell System: Inhibition of Apoptosis and Increase of EPO Production" Biotechnology and Bioengineering, 91(7), 793-800 (2005).  

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• Ji Eun Kim, Eun Jeong Kim, Won Jong Rhee, Tai Hyun Park "Enhanced Production of Recombinant Protein in Escherichia coli Using Silkworm Hemolymph" Biotechnology and Bioprocess Engineering, 10, 353-356 (2005).  

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• Eun Jeong Kim, Won Jong Rhee, Tai Hyun Park "Inhibition of Apoptosis by a Bombyx mori Gene" Biotechnology Progress, 20, 324-329 (2004).  

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• Won Jong Rhee, Eun Jeong Kim, Tai Hyun Park "Silkworm hemolymph as a potent inhibitor of apoptosis in Sf9 cells" Biochemical and Biophysical Research Communications, 295, 779-783 (2002).   

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• Shin Sik Choi, Won Jong Rhee, Tai Hyun Park "Inhibition of Human Cell Apoptosis by Silkworm Hemolymph" Biotechnology Progress, 18, 874-878 (2002).  

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• Won Jong Rhee, Tai Hyun Park "Flow cytometric analysis of the effect of silkworm hemolymph on the baculovirus-induced insect cell apoptosis" Journal of Microbiology and Biotechnology, 11(5), 853-857 (2001).  

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• Eun Jeong Kim, Won Jong Rhee, Tai Hyun Park "Isolation and Characterization of an Apoptosis-Inhibiting Component from the Hemolymph of Bombyx mori" Biochemical and Biophysical Research Communications, 285, 224-228 (2001).   

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• Won Jong Rhee, Tai Hyun Park "Silkworm Hemolymph Inhibits Baculovirus-Induced Insect Cell Apoptosis" Biochemical and Biophysical Research Communications, 271, 186-190 (2000).  

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• Won Jong Rhee, Eun Jeong Kim, Tai Hyun Park "Kinetic Effect of Silkworm Hemolymph on the Delayed Host Cell Death in an Insect Cell-Baculovirus System" Biotechnology Progress, 15, 1028-1032 (1999).